Ueber eine neue Klasse von Schlafmitteln.

8vo. (175 x 115 mm) 16 pp.; two short marginal tears not affecting text. Original printed wrappers; centre fold mark. Exlib ink stamp on cover, bookplate of Andras Gedeon. Fine. FIRST SEPARATE EDITION of the discovery of diethyl barbituric acid. "Fischer and Mering investigate the hypnotic effect of various derivatives of barbituric acid and related substances. . . This led to the seminal discovery of the hypnotic action of diethylbarbituric acid." This work introduced an entirely new synthetic drug called Veronal, a barbiturate family still of major importance in clinical medicine. [Gedeon]. Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. / "Barbital was first produced in 1882 by Max Conrad and Max Guthzeit without further identification. Twenty years later, in 1902, it was first synthesized by the German Emil Fischer and his nephew Alfred Dilthey and characterized as a sleeping pill by Josef von Mering. Barbital was brought onto the market in tablet form by Merck in 1903 as the first barbiturate under the brand name Veronal. It had not become established as an anesthetic because of its toxic side effects in higher doses, but was used as a strong sedative as part of premedication before anaesthesia. In combination with amidopyrine, it was advertised for many years as Veramon, among others, also as a remedy for menstrual cramps, sold by Schering-Kahlbaum AG. Finished medicines containing barbital are no longer available worldwide today." Garrison and Morton 1892; Gedeon, Science and technology in medicine, pp. 372-5.

Product Info

Publisher: Urban & Schwarzenberg, 1903.

Year: 1903

Type: Used

Binding: Softcover

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